What Is hs-CRP?
C-reactive protein (CRP) is made by the liver in response to inflammation. The high-sensitivity CRP (hs-CRP) test measures very low levels of CRP and is used to assess low-grade inflammation linked to cardiovascular risk.
Commonly used cardiovascular risk categories are:
- Below 1.0 mg/L: Lower risk
- 1.0 to 3.0 mg/L: Average risk
- Above 3.0 mg/L: Higher risk
What Can Raise CRP Besides Heart Disease?
CRP is not specific to the heart—it rises with inflammation from almost any source. Common causes include:
- Recent infections: A cold, flu, sinus infection, or dental infection can raise CRP for days to a couple of weeks
- Intense exercise: Very hard workouts, long-distance running, or heavy lifting can temporarily raise CRP
- Injuries or recent surgery
- Excess body fat: Fat tissue produces inflammatory signals
- Smoking
- Poor sleep and chronic stress
- Autoimmune or inflammatory conditions: Such as rheumatoid arthritis or inflammatory bowel disease
- Gum disease
- Hormone therapy: Oral estrogen can raise CRP
- Pregnancy
Could a Cold or Workout Throw It Off?
Yes. Because of this, hs-CRP results are best interpreted when you're feeling well. Guidelines suggest:
- Avoid testing during or right after an illness
- Avoid very intense exercise for a day or two beforehand
- Repeat the test if the result is elevated, ideally a couple of weeks apart
- A result above 10 mg/L usually points to an acute infection or inflammatory condition and should be rechecked
How to Lower Chronic Inflammation
- Exercise regularly (moderate, consistent activity lowers CRP over time)
- Lose excess weight
- Don't smoke
- Eat an anti-inflammatory diet rich in vegetables, fruit, fish, and olive oil
- Sleep 7–9 hours
- Take care of your teeth and gums
Learn more about lab testing here: Heva Lab Testing
The Bottom Line
hs-CRP is a useful marker of inflammation and heart risk, but colds, workouts, injuries, and many other factors can raise it. Test when you're well and repeat elevated results before drawing conclusions.